Epstein-Barr virus and human herpesvirus 8 coinfection and concomitant extranodal nasal-type NK/T cell lymphoma and Castleman disease: case report.
نویسندگان
چکیده
We describe a 36-year-old man uninfected with human immunodeficiency virus who had confirmed concurrent infection with Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV-8) and their respective lymphoproliferative manifestations, nasal-type NK/T cell lymphoma and Castleman disease. Antibodies to HHV-8 and EBV DNA were found in plasma and peripheral blood mononuclear cells. An EBV-positive nasal-type NK/T cell lymphoma infiltrated the splenic red pulp, whereas the white pulp contained HHV-8-positive plasmablasts, as found in Castleman disease.
منابع مشابه
Imaging Case: NK/T-Cell Lymphoma, Nasal Type
Peripheral T-cell lymphomas are a group of heterogeneous disorders and according to WHO classification, are categorized into nodal and extranodal forms. NK/T-cell lymphoma, nasal type, is a subtype of extranodal peripheral T-cell lymphoma and commonly presents as a midfacial destructive lesion. This disorder is more prevalent in Asia and South America and has a strong association with Epstein B...
متن کاملExtranodal NK/T Cell Lymphoma with Destruction of the Uvulae: A Case Report
Introduction: Extranodal Natural Killer (NK)/T-cell lymphoma (NKTCL) nasal type is a rare but well-known disease with poor prognosis. NKTCL is more prevalent in Asia and comprises about 7-10% of all non-Hodgkin lymphoma cases in this region. The characteristic clinical pattern of NKTCL is the destruction of the midline structures of the mid-face. Case Report: The present study examines a case o...
متن کاملClinico-Radiologic Findings in Primary Cutaneous Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type Mimicking Cellulitis of the Left Arm (Case Report)
Extranodal natural killer (NK)/T-cell lymphoma is a very rare and aggressive disease characterized histopathologically by an Epstein-Barr virus (EBV)-positive atypical lymphoid cytotoxic infiltrate, extensive vascular destruction, and prominent tissue necrosis. It commonly shows cutaneous lesions that primarily or secondarily mimic cellulitis at the primary site. We report on a very rare case o...
متن کاملT-cell lymphoma 229 EPSTEIN-BARR VIRUS DNA IN PERIPHERAL BLOOD AND EXTRANODAL NK/T-CELL LYMPHOMA, NASAL TYPE
Background: Peripheral blood of patients with extranodal NK/T-cell lymphoma, nasal type (ENKL) contains fragmented Epstein-Barr virus (EBV) DNA. Measurement of the circulating viral DNA load has been reported to be useful for diagnosis, monitoring and prognostication of the disease. However, there are two different subjects for analysis, plasma and mononuclear cells (MNC). It remains unclear wh...
متن کاملCurrent Management of Nasal NK/T-cell Lymphoma
Nasal natural killer (NK)/T-cell lymphoma is a unique type of non-Hodgkin lymphoma (NHL) that is almost always associated with Epstein-Barr virus (EBV). The disease predominantly localizes to the upper aerodigestive tract, most commonly in the nose. It is locally angioinvasive and destructive and was previously called lethal midline granuloma. However, up to 25% of patients have primary extrana...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
دوره 36 9 شماره
صفحات -
تاریخ انتشار 2003